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Knowing that size plays a deciding factor in performance what separates one module from another? In a word, speed. Every module is assigned a speed rating from the manufacture that is largely dependent on the quality of the chips but can also be affected by module (PCB) design, the voltage requirements, and settings required to maintain a given level of performance. This roughly translates into frequency and latency.
We here at Ninjalane are rather picky when it comes to purchasing memory for our own machines. In fact we'll often pay quite a bit extra to get a good performing module with a high speed rating and extremely low latency. In the DDR2 world this is a PC8500 capable product running CAS5 or lower.